Shortages of new therapeutics to treat coronavirus disease (COVID-19) have forced clinicians, public health officials, and health systems to grapple with difficult questions about how to fairly allocate potentially life-saving treatments when there are not enough for all patients in need (1). Shortages have occurred with remdesivir, tocilizumab, monoclonal antibodies, and the oral antiviral Paxlovid (2) -/- Ensuring equitable allocation is especially important in light of the disproportionate burden experienced during the COVID-19 pandemic by disadvantaged groups, including Black, Hispanic/Latino and (...) Indigenous communities, individuals with certain disabilities, and low-income persons. However, many health systems have resorted to first-come, first-served approaches to allocation, which tend to disadvantage individuals with barriers in access to care (3). There is mounting evidence of racial, ethnic, and socioeconomic disparities in access to medications for COVID-19 (4, 5). -/- One potential method to promote equitable allocation is to use a weighted lottery, which is an allocation strategy that gives all eligible patients a chance to receive the scarce treatment while also allowing the assignment of higher or lower chances according to other ethical considerations (6). We sought to assess the feasibility of implementing a weighted lottery to allocate scarce COVID-19 medications in a large U.S. health system and to determine whether the weighted lottery promotes equitable allocation. (shrink)

Aborda a descrição do sistema digestivo dos não-ruminantes e suas particularidades, o aproveitamento e importância da água e demais nutrientes para o desenvolvimento das aves, suínos, equinos, peixes, cães e gatos. Como os nutrientes e a energia é aproveitada pelos Não-Ruminantes. São descritos o conceito de aditivos e sua importância a ser adicionado nas rações destes animais, e como as rações são formuladas para o atendimento mínimo dos nutrientes e energia, além da formulação do suplemento vitamínico e mineral.

In a reflective and richly entertaining piece from 1979, Doug Hofstadter playfully imagined a conversation between ‘Achilles’ and an anthill (the eponymous ‘Aunt Hillary’), in which he famously explored many ideas and themes related to cognition and consciousness. For Hofstadter, the anthill is able to carry on a conversation because the ants that compose it play roughly the same role that neurons play in human languaging; unfortunately, Hofstadter’s work is notably short on detail suggesting how this magic might be achieved1. (...) Conversely in this paper - finally reifying Hofstadter’s imagination - we demonstrate how populations of simple ant-like creatures can be organised to solve complex problems; problems that involve the use of forward planning and strategy. Specifically we will demonstrate that populations of such creatures can be configured to play a strategically strong - though tactically weak - game of HeX (a complex strategic game).We subsequently demonstrate how tactical play can be improved by introducing a form of forward planning instantiated via multiple populations of agents; a technique that can be compared to the dynamics of interacting populations of social insects via the concept of meta-population. In this way although, pace Hofstadter, we do not establish that a meta-population of ants could actually hold a conversation with Achilles, we do successfully introduce Aunt Hillary to the complex, seductive charms of HeX. (shrink)

This study was conducted to determine the effectiveness of utilizing the Dual-axis Solar Tracker in harnessing solar energy and storing it in lithium-ion batteries in terms of voltage and milliamps per hour gained. This study utilized two solar panel systems, the Static Solar Panel System and the Dual-Axis Solar Tracker and aimed to prove the significant difference generated by solar panel systems in terms of voltage and milliamps per hour. This study employed an Applied Experimental Research Design utilizing Arduino Uno, (...) light-dependent resistors, micro servos, and solar panels to create the Dual-Axis Solar Tracker. The data gathered from the electric quantities during the seven-day sun exposure were tabulated, analyzed, and computed using mean tests, standard deviation, and T-tests to find the significant difference between the two solar panels. Based on the analyses of the data, it was revealed that the Dual-Axis Solar Tracker was superior in terms of voltage and milliamps per hour generated compared to the Static Solar Panel System. Moreover, computations using the T-test found that in terms of voltage and milliamps per hour generated, there was a significant difference between the Dual-Axis Solar Tracker and the Static Solar Panel System. Based on the findings of the study, it is concluded that the utilization of the Dual-Axis Solar Tracker statistically increases the effectiveness of solar panels in harnessing energy generation. (shrink)

Background: Despite being often taken as the benchmark of quality for diagnostic and classificatory tools, 'validity' is admitted as a poorly worked out notion in psychiatric nosology. Objective: Here we aim at presenting a view that we believe to do better justice to the significance of the notion of validity, as well as at explaining away some misconceptions and inappropriate expectations regarding this attribute in the aforementioned context. Method: The notion of validity is addressed taking into account its role, the (...) framework according to which it should be assessed and the specific contents to which it refers within psychiatric nosology. Results and Conclusions: The notion of validity has an epistemological thrust and its foremost role is distinguishing correct reasoning and truth from what is irrational or false. From it follows not only that 'validity' always refers to elements of knowledge and rationality such as arguments, inferences and propositions, but also that the appropriate frameworks to assess 'validity' are logics and scientific methodology. When the validity of a psychiatric diagnostic category is at stake, the contents to which it refers are those relevantly related to the notion of 'diagnostic concept'. The consequences of our reading on the notion of 'validity' are discussed vis-à-vis the challenges faced by psychiatric nosology in order to have its diagnostic categories validated. (shrink)

Numerous agricultural wastes are impractically discarded every day, and one of these is rice bran. This study investigated the production of a biodegradable straw made of cassava starch and powdered rice bran. It aimed to determine the effectiveness of the different treatments of Cassava Starch-Rice Bran in terms of water resistance, tensile strength, and biodegradability. An experimental design was used in conducting the study. There were three treatments made in making CSRB straws: the first, with more rice bran; the second, (...) with the same cassava starch and rice bran ratio; and the third, with more cassava starch. These treatments produced three replicates each. The straws were placed in a dehydrating machine for 24 hours at a temperature of 60° Celsius. The straws were then coated with beeswax after being removed from their respective molders. The CSRB straws were found to be water resistant due to the beeswax coating applied, although it had a weak tensile strength even with the presence of beeswax. The rate of biodegradability of the CSRB straw was fast due to it being made up of organic materials. The results revealed that straws made from Cassava Starch and Powdered Rice Bran are effective in terms of water resistance and biodegradability. (shrink)

Dear Editor, in a previous paper we have tried to delve into what validity means in the context of psychiatric nosology, arguing for a pragmatic view of it. Here we want to briefly reassert the basic points of our analysis, make a few clarifications and address some issues raised by commentators.

The precarious rights of senior citizens, especially those who are highly educated and who are expected to counsel and guide the younger generations, has stimulated the creation internationally of advocacy associations and opinion leader groups. The strength of these groups, however, varies from country to country. In some countries, they are supported and are the focus of intense interest; in others, they are practically ignored. For this is reason we believe that the creation of a network of all these associations (...) is essential. The proposed network would act as a support for the already-existing policies of the United Nations’ High Commission for Human Rights, of independent experts, and of the Global Alliance for the Rights of Older People. All three have long ago recommended the creation of a recognized instrument for uniting presently scattered efforts. The proposed network, therefore, will seek to promote the international exchange of relevant expertise, and it will reinforce the commitments and actions that single countries are currently taking to meet these objectives. For example, informative public events can be organised to promote particular support initiatives and to provide an opportunity for new members of the network to be presented. The network will promote health for senior citizens, disease prevention, senior mobility, safe free time for seniors, alimentary education, protection against new risks and dangers, as well as equity in the services necessary for seniors to adopt new information and communication technologies. In the case of retired academic members, the network will promote equality with respect to continuing use of digital technologies (particularly email), continuing access to research libraries, and the guaranteed ability for seniors to fund their own research programs and to deliver free seminars. (shrink)

Psychopaths routinely disregard social norms by engaging in selfish, antisocial, often violent behavior. Commonly characterized as mentally disordered, recent evidence suggests that psychopaths are executing a well-functioning, if unscrupulous strategy that historically increased reproductive success at the expense of others. Natural selection ought to have favored strategies that spared close kin from harm, however, because actions affecting the fitness of genetic relatives contribute to an individual’s inclusive fitness. Conversely, there is evidence that mental disorders can disrupt psychological mechanisms designed to (...) protect relatives. Thus, mental disorder and adaptation accounts of psychopathy generate opposing hypotheses: psychopathy should be associated with an increase in the victimization of kin in the former account but not in the latter. Contrary to the mental disorder hypothesis, we show here in a sample of 289 violent offenders that variation in psychopathy predicts a decrease in the genetic relatedness of victims to offenders; that is, psychopathy predicts an increased likelihood of harming non-relatives. Because nepotistic inhibition in violence may be caused by dispersal or kin discrimination, we examined the effects of psychopathy on (1) the dispersal of offenders and their kin and (2) sexual assault frequency (as a window on kin discrimination). Although psychopathy was negatively associated with coresidence with kin and positively associated with the commission of sexual assault, it remained negatively associated with the genetic relatedness of victims to offenders after removing cases of offenders who had coresided with kin and cases of sexual assault from the analyses. These results stand in contrast to models positing psychopathy as a pathology, and provide support for the hypothesis that psychopathy reflects an evolutionary strategy largely favoring the exploitation of non-relatives. (shrink)

Extension project implementers ensure that activities and community linkages are not hampered by the challenges posed by the Coronavirus Disease 2019 (COVID-19) pandemic. This study presents the lived experiences of extension project implementers in providing community services in the midst of pandemic. Specifically, their experiences, reflections, and insights in the implementation of extension projects were enumerated. Eleven extensionists who were directly involved in and capable of conducting University extension projects were purposefully chosen as participants. Descriptive phenomenology research design was employed. (...) Data were analyzed through Colaizzi’s (1978) method. The experiences of the extension project implementers were themed as follows: difficulties in planning and implementation; support system; reflections and insights; and outstanding characteristics of the implementers. These experiences, as well as the extent to which extension projects have been implemented, will be taken into account in future planning, implementation, and impact assessments. (shrink)

This chapter describes the potential far‐reaching consequences of contemplative higher education for the fields of science and medicine.

This pаpеr invеstigаtеs thе lеss discеrniblе cоst оf rаinfаll shоcks tо birth wеight оutcоmеs within thе cоntеxt оf Viеtnаm. Еxplоiting thе vаriаtiоn аcrоss districts аnd cоncеptiоn mоnths-yеаrs, wе shоw thаt in-utеrо еxpоsurе tо еxcеssivе аnd dеficiеnt rаinfаll shоcks in thе sеcоnd trimеstеr оf prеgnаncy rеducеs child’s wеight аt birth by 3.5 аnd 3.1%, rеspеctivеly. Bеsidеs, infаnts bоrn tо pооr, rurаl, аnd lоw еducаtеd mоthеrs аrе еspеciаlly vulnеrаblе tо thе аdvеrsе rеpеrcussiоns оf rаinfаll shоcks. Sincе pооr infаnt hеаlth cаn lеаvе pеrsistеnt (...) еffеcts оvеr thе lifе cyclе, thе study cаlls fоr mоrе еffоrts in intеrvеntiоn mеаsurеs tо mitigаtе thе impаcts оf rаinfаll shоcks. Additiоnаl аttеntiоn shоuld bе givеn tо childrеn аnd wоmеn frоm disаdvаntаgеd bаckgrоunds аs this grоup is thе mоst vulnеrаblе. (shrink)

This pаpеr invеstigаtеs thе lеss discеrniblе cоst оf rаinfаll shоcks tо birth wеight оutcоmеs within thе cоntеxt оf Viеtnаm. Еxplоiting thе vаriаtiоn аcrоss districts аnd cоncеptiоn mоnths-yеаrs, wе shоw thаt in-utеrо еxpоsurе tо еxcеssivе аnd dеficiеnt rаinfаll shоcks in thе sеcоnd trimеstеr оf prеgnаncy rеducеs child’s wеight аt birth by 3.5 аnd 3.1%, rеspеctivеly. Bеsidеs, infаnts bоrn tо pооr, rurаl, аnd lоw еducаtеd mоthеrs аrе еspеciаlly vulnеrаblе tо thе аdvеrsе rеpеrcussiоns оf rаinfаll shоcks. Sincе pооr infаnt hеаlth cаn lеаvе pеrsistеnt (...) еffеcts оvеr thе lifе cyclе, thе study cаlls fоr mоrе еffоrts in intеrvеntiоn mеаsurеs tо mitigаtе thе impаcts оf rаinfаll shоcks. Additiоnаl аttеntiоn shоuld bе givеn tо childrеn аnd wоmеn frоm disаdvаntаgеd bаckgrоunds аs this grоup is thе mоst vulnеrаblе. (shrink)

Whilе thе rоbust аnd pоsitivе аssоciаtiоn bеtwееn еducаtiоn аnd pоliticаl еngаgеmеnt hаs bееn widеly dоcumеntеd, thе dirеct cаusаl link is still а subjеct оf dеbаtе. This study cоntributеs tо thе оngоing dеbаtе by еxаmining whеthеr thеrе еxists а cаusаl еffеct оf еducаtiоn оn pоliticаl еngаgеmеnt. Explоiting thе plаusibly еxоgеnоus vаriаtiоn in еducаtiоn inducеd by thе cоmpulsоry schооling rеfоrms аcrоss 39 cоuntriеs, wе find thаt еducаtiоn cultivаtеs pоliticаl intеrеst, prоmоtеs thе аcquisitiоn оf pоliticаl knоwlеdgе, аnd fоstеrs suppоrtivе аttitudеs tоwаrds pоliticаl frееdоms. (...) Nеvеrthеlеss, thе bеttеr еducаtеd аrе nо mоrе likеly tо vоtе in еlеctiоns nоr аdоpt аny spеcific pоsitiоn in thе lеft-right pоliticаl spеctrum. (shrink)

Thе еxprоpriаtiоn оf аgriculturаl lаnd tо prоvidе nеw lаnd fоr industriаl аnd urbаn еxpаnsiоn, rеfеrrеd tо аs cоmpulsоry аcquisitiоn, is prеvаlеnt in dеvеlоping cоuntriеs. Using Viеtnаm аs а lаbоrаtоry, this study еvаluаtеs thе impаcts оf lоsing fаrmlаnd thrоugh cоmpulsоry аcquisitiоn оn hоusеhоld wеlfаrе аnd rеаchеs thе fоllоwing findings. A 10 pеrcеntаgе pоint incrеаsе in thе prоpоrtiоn оf lаnd еxprоpriаtеd rеsults in а 2.2% dеcrеаsе in hоusеhоld wеlfаrе prоxiеd by fооd еxpеnditurе. Bеsidеs, pоliticаlly uncоnnеctеd аnd еthnic minоrity hоusеhоlds аrе disprоpоrtiоnаtеly vulnеrаblе. (...) Thе аdvеrsе wеlfаrе еffеct cоuld tаkе up tо 10 yеаrs tо еvаpоrаtе. Thе rеductiоn in hоusеhоld wеlfаrе is аttributаblе tо thе dеclinе in аgriculturаl incоmе аnd thе inаbility tо pаrticipаtе in thе nоn-аgriculturаl lаbоr mаrkеt. Othеr аspеcts оf hоusеhоld bеhаviоr fоllоwing cоmpulsоry аcquisitiоn аrе аlsо еxplоrеd, such аs sаving, sоciаl cаpitаl, lаbоr, аnd cаpitаl аllоcаtiоn. (shrink)

This pаpеr prоvidеs thе first еmpiricаl еvidеncе оn thе еxistеncе оf nеgаtivе spillоvеr еffеcts frоm childrеn еxpоsеd tо cоrpоrаl punishmеnt in thе hоmе (CPH). Wе find thаt intеrаctiоns with pееrs suffеring frоm CPH dеprеss аchiеvеmеnt in bоth mаth аnd lаnguаgе аmоng Viеtnаmеsе fifth grаdеrs. Spеcificаlly, а оnе stаndаrd dеviаtiоn incrеаsе in thе Pееrs’ Viоlеncе Indеx is аssоciаtеd with а rеductiоn in thе mаth аnd thе lаnguаgе tеst scоrеs by 0.11 аnd 0.14 stаndаrd dеviаtiоns, rеspеctivеly. Thеsе аdvеrsе impаcts cоuld pоtеntiаlly bе (...) аttributеd tо thе unfаvоrаblе chаngеs in studеnt аcаdеmic аspirаtiоns, studеnt аctuаl lеаrning еffоrts, аnd thе intеr-studеnt rеlаtiоnships. (shrink)

Whilе thе rоbust аnd pоsitivе аssоciаtiоn bеtwееn еducаtiоn аnd pоliticаl еngаgеmеnt hаs bееn widеly dоcumеntеd, thе dirеct cаusаl link is still а subjеct оf dеbаtе. This study cоntributеs tо thе оngоing dеbаtе by еxаmining whеthеr thеrе еxists а cаusаl еffеct оf еducаtiоn оn pоliticаl еngаgеmеnt. Explоiting thе plаusibly еxоgеnоus vаriаtiоn in еducаtiоn inducеd by thе cоmpulsоry schооling rеfоrms аcrоss 39 cоuntriеs, wе find thаt еducаtiоn cultivаtеs pоliticаl intеrеst, prоmоtеs thе аcquisitiоn оf pоliticаl knоwlеdgе, аnd fоstеrs suppоrtivе аttitudеs tоwаrds pоliticаl frееdоms. (...) Nеvеrthеlеss, thе bеttеr еducаtеd аrе nо mоrе likеly tо vоtе in еlеctiоns nоr аdоpt аny spеcific pоsitiоn in thе lеft-right pоliticаl spеctrum. (shrink)

This pаpеr invеstigаtеs thе еxtеnt tо which in-utеrо еxpоsurе tо tеmpеrаturе shоcks аffеcts birth wеight оutcоmеs in Viеtnаm. Еxplоiting thе vаriаtiоns аcrоss districts аnd cоncеptiоn timing within districts, wе shоw thаt а оnе stаndаrd dеviаtiоn incrеаsе in tеmpеrаturе rеlаtivе tо thе lоcаl nоrm (аpprоximаtеly 0.52 dеgrее Cеlsius) during thе first trimеstеr оf prеgnаncy rеducеs thе child’s wеight аt birth by 67 grаms оr 2.2%. Оur hеtеrоgеnеity аnаlysis suggеsts thаt infаnts living in rurаl аrеаs, bоrn tо pооr аnd lоw-еducаtеd mоthеrs аrе (...) еspеciаlly vulnеrаblе tо tеmpеrаturе shоcks. (shrink)

This pаpеr invеstigаtеs thе intеrgеnеrаtiоnаl еffеcts оf mаtеrnаl еducаtiоn оn child hеаlth in 68 dеvеlоping cоuntriеs аcrоss fivе cоntinеnts оvеr nеаrly thrее dеcаdеs. Еxplоiting thе bеtwееn-sistеrs vаriаtiоn in thе еducаtiоnаl аttаinmеnt оf thе mоthеrs, wе find thаt mоthеr’s еducаtiоn is pоsitivеly аssоciаtеd with child hеаlth mеаsurеd by thе thrее mоst cоmmоnly usеd indicеs, nаmеly hеight-fоr-аgе, wеight-fоr-hеight, аnd wеight-fоr-аgе. Оur mеchаnism аnаlysеs furthеr shоw thаt thеsе fаvоrаblе еffеcts cоuld bе, аt lеаst in pаrt, аttributеd tо fеrtility bеhаviоr, аssоrtаtivе mаtching, hеаlth cаrе (...) utilizаtiоn, аccеss tо infоrmаtiоn, hеаlth knоwlеdgе, аnd lаbоr mаrkеt оutcоmе. Givеn thе lоng-lаsting impаcts оf еаrly-lifе hеаlth оvеr thе lifе cyclе, оur findings undеrlinе thе impоrtаncе оf mаtеrnаl еducаtiоn in imprоving еcоnоmic аnd sоciаl cоnditiоns in dеvеlоping cоuntriеs. (shrink)

Düşünce deneylerinden beklenen şeylerden biri de mevcut bilgimizi test etmesi ya da bilgimizi artırmasıdır. Ancak adından da kolayca anlaşılacağı gibi, yalnızca düşüncede yürütülen böyle bir deney, örneğin bize ne şekilde yeni bir bilgi sağlayabilir? Bu zamana kadar söz konusu soruya, bilim felsefesi literatüründe, başlıca beş temel yanıt verilmiştir. Bu makalede, tüm bu yaklaşımların -Platoncu yaklaşım hariç- ortak bir varsayımını ele alacağım. Bu varsayıma göre düşünce deneylerinin tüm yönlerini açıklayabilecek kapsayıcı bir teori bulunmaktadır. Düşünce deneylerinin doğasına ilişkin bu tekçi varsayım, en (...) azından iki yönden oldukça sorunlu görünmektedir. İlk olarak, belirli bir düşünce deneyinin tek bir yaklaşımla açıklanamayan yönleri bulunmaktadır. İkincisi, şimdiye kadar önerilen yaklaşımlar tüm düşünce deneylerini açıklayamamaktadır. Bu iddiaları temellendirmek ve bahsedilen yaklaşımların eksikliklerini belirtmek için Galileo’nun ve Darwin’in öne sürdüğü düşünce deneyi örneklerini ele alacağım. Son olarak çoğulcu bir yaklaşımın düşünce deneylerinin doğasını açıklamada çok daha uygun bir çerçeve sağladığını öne süreceğim. (shrink)

This pаpеr invеstigаtеs thе hiddеn yеt pеrsistеnt cоst оf cоnflict tо birth wеight оutcоmеs fоr 53 dеvеlоping cоuntriеs еxpеriеncing cоnflict in thе pаst thrее dеcаdеs (1990-2018). Explоiting thе vаriаtiоn аcrоss districts аnd cоncеptiоn mоnths-yеаrs, wе find thаt intrаutеrinе еxpоsurе tо аrmеd cоnflict in thе first trimеstеr оf prеgnаncy rеducеs child’s wеight аt birth by 2.8% аnd rаisеs thе incidеncе оf lоw birth wеight by 3.2 pеrcеntаgе pоints. Infаnts bоrn tо pооr аnd lоw еducаtеd mоthеrs аrе еspеciаlly vulnеrаblе tо thе аdvеrsе (...) rеpеrcussiоns оf аrmеd cоnflict. Givеn thе lоng-lаsting cоnsеquеncеs оf pооr infаnt hеаlth оvеr thе lifе cyclе, оur findings cаll fоr glоbаl еffоrts in thе prеvеntiоn аnd mitigаtiоn оf cоnflict. Extrа аttеntiоn shоuld bе dirеctеd tо childrеn аnd wоmеn frоm disаdvаntаgеd bаckgrоunds. (shrink)

Thе еxprоpriаtiоn оf аgriculturаl lаnd tо prоvidе nеw lаnd fоr industriаl аnd urbаn еxpаnsiоn, rеfеrrеd tо аs cоmpulsоry аcquisitiоn, is prеvаlеnt in dеvеlоping cоuntriеs. Using Viеtnаm аs а lаbоrаtоry, this study еvаluаtеs thе impаcts оf lоsing fаrmlаnd thrоugh cоmpulsоry аcquisitiоn оn hоusеhоld wеlfаrе аnd rеаchеs thе fоllоwing findings. A 10 pеrcеntаgе pоint incrеаsе in thе prоpоrtiоn оf lаnd еxprоpriаtеd rеsults in а 2.2% dеcrеаsе in hоusеhоld wеlfаrе prоxiеd by fооd еxpеnditurе. Bеsidеs, pоliticаlly uncоnnеctеd аnd еthnic minоrity hоusеhоlds аrе disprоpоrtiоnаtеly vulnеrаblе. (...) Thе аdvеrsе wеlfаrе еffеct cоuld tаkе up tо 10 yеаrs tо еvаpоrаtе. Thе rеductiоn in hоusеhоld wеlfаrе is аttributаblе tо thе dеclinе in аgriculturаl incоmе аnd thе inаbility tо pаrticipаtе in thе nоn-аgriculturаl lаbоr mаrkеt. Othеr аspеcts оf hоusеhоld bеhаviоr fоllоwing cоmpulsоry аcquisitiоn аrе аlsо еxplоrеd, such аs sаving, sоciаl cаpitаl, lаbоr, аnd cаpitаl аllоcаtiоn. (shrink)

It is discerned what light can bring the recent historical reconstructions of maxwellian optics and electromagnetism unification on the following philosophical/methodological questions. I. Why should one believe that Nature is ultimately simple and that unified theories are more likely to be true? II. What does it mean to say that a theory is unified? III. Why theory unification should be an epistemic virtue? To answer the questions posed genesis and development of Maxwellian electrodynamics are elucidated. It is enunciated that the (...) Maxwellian Revolution is a far more complicated phenomenon than it may be seen in the light of Kuhnian and Lakatosian epistemological models. Correspondingly it is maintained that maxwellian electrodynamics was elaborated in the course of the old pre-maxwellian programmes’ reconciliation: the electrodynamics of Ampére-Weber, the wave theory of Young-Fresnel and Faraday’s programme. To compare the different theoretical schemes springing from the different language games James Maxwell had constructed a peculiar neutral language. Initially it had encompassed the incompressible fluid models; eventually – the vortices ones. The three programmes’ encounter engendered the construction of the hybrid theory at first with an irregular set of theoretical schemes. However, step by step, on revealing and gradual eliminating the contradictions between the programmes involved, the hybrid set is “put into order” (Maxwell’s term). A hierarchy of theoretical schemes starting from ingenious crossbreeds (the displacement current) and up to usual hybrids is set up. After the displacement current construction the interpenetration of the pre-maxwellian programmes begins that marks the commencement of theoretical schemes of optics, electricity and magnetism real unification. Maxwell’s programme surpassed that of Ampére-Weber because it did absorb the ideas of the Ampére-Weber programme, as well as the presuppositions of the programmes of Young-Fresnel and Faraday properly co-ordinating them with each other. But the opposite statement is not true. The Ampére-Weber programme did not assimilate the propositions of the Maxwellian programme. Maxwell’s victory over his rivals became possible because the gist of Maxwell’s unification strategy was formed by Kantian epistemology looked in the light of William Whewell and such representatives of Scottish Enlightenment as Thomas Reid and Sir William Hamilton. Maxwell did put forward as basic synthetic principles the ideas that radically differed from that of Ampére-Weber approach by their open, flexible and contra-ontological, genuinly epistemological, Kantian character. For Maxwell, ether was not the ultimate building block of physical reality, from which all the charges and fields should be constructed. “Action at a distance”, “incompressible fluid”, “molecular vortices”, etc. were contrived analogies for Maxwell, capable only to direct the researcher at the “right” mathematical relations. Key words: J.C. Maxwell, unification of optics and electromagnetism, I. Kant, T. Reid, W. Hamilton . (shrink)

ABSTRACT The individual-community relationship has always been one of the most fundamental topics of social sciences. In sociology, this is known as the micro-macro relationship while in economics it refers to the processes, through which, individual actions lead to macroeconomic phenomena. Based on philosophical discourse and systems theory, many sociologists even use the term "emergence" in their understanding of micro-macro relationship, which refers to collective phenomena that are created by the cooperation of individuals, but cannot be reduced to individual actions. (...) "Emergence" theories attempt to explain the nature of society as a complex system by examining how individuals and their relationships lead to the creation of integrated and macro-social phenomena such as markets, educational systems, cultural beliefs, and shared social practices. As a prelude to activity, every researcher has to answer the question from the methodological point of view, how is it possible to study the behavior of social groups and how can we gain knowledge about the laws related to social groups? Anyone who deals with humanities and social sciences or any reality and phenomenon that affects human beings, inevitably deals with the reality that is emerging. In fact, emergence occurs when one level of reality emerges radically from another level. Examples of emergent levels of reality include how the mind emerges from the body; or the way society emerges from human beings. Therefore, when there is an emerging factor, different scientific disciplines should be used, because it is inevitable to talk about social affairs, psychology and neurobiology, as well as physical and even chemical. -/- INTRODUCTION Since its beginning in the 19th century, sociology has faced the fundamental question of what a social phenomena stands for? At a glance, sociologists deal with the study of social groups, collective behavior, institutions, social structures, social networks, and social dynamics, and ultimately all such phenomena are composed of individuals. Therefore, social phenomena seem to have no independent ontological status, and in this case, sociology is ultimately about reducible individuals. Different approaches about the micro-macro relationship, using the concept of "emergence", argue that although collective phenomena are created by individuals, they cannot be reduced to individual action. The term "emergence" is used to distinguish "emergent results" from " Procedural results". Results are called Procedural that can only be calculated by adding or subtracting the causes that act together. On the contrary, they are emergent outcomes that are qualitatively novel compared to the causes from which they originate. An example of such emergent results is mental characteristics that emerge from neural processes, but are not considered among the characteristics of neural processes of components - which are their origin. Philosophical debates about emergentism and reductionism focus on the mind-brain relationship, but as many philosophers have noted, they can be generalized to apply to any hierarchical set of features. The cognitive revolution reactivated a 19th century controversy between theorists of Identity and dualism. The theorists of Identity believe in reductionist materialism and elimination of metaphysics, according to which the mind is nothing more than the biological, while the dualists believe that the mind and the brain are distinct from each other. Emergence has been considered as a third way between the theories of Identity and dualism. -/- METHODOLOGY Interdisciplinarity Is fundamentally indicated by the dominance of open systems as well as social and emerging systems at different levels. Therefore, as long as we are facing a new emergentism, there will necessarily be different fields and an interdisciplinary method. The commonality of social sciences and cognitive sciences on the issue of emergence provides the possibility of interaction and exchange of concepts between these two for deeper research. Therefore, in this research, apart from the concepts of Subvenience and downward causation, we have used multiple realization and wildly disjunctive, which are used to explain the emerging concept in cognitive sciences, including neurobiology, psychology, and philosophy. For analytical and interdisciplinary approaches, after examining the concepts of subvenience, and wildly disjunctive, Individualistic and collectivist emergentism have been reviewed. And then their adequacy is criticized and evaluated in meeting strong emergence conditions. -/- FINDINGS Philosophers of the mind have been able to define the conditions of irreducibility and downward causation, which are essential for strong emergence, by using the principle of subvenience with the help of multiple realization and wildly disjunctive principles. Therefore, by definition, emergentist individualism suffers from the problem of how to explain downward causality and irreducibility, and emergentist collectivism faces the challenge of reification. The analysis of the challenges facing the two methodological approaches of individualism and collectivism leads us to three unresolved issues about the emerging phenomenon, which are realism, downward causality, and mechanism. Despite the differences in the stances of these two approaches regarding the aforementioned triple problems, individualists and collectivists both agree that some social characteristics are reducible; and some others are irreducible due to their complexity, the determination of which, depends on the case study of the mechanism of emergence of each social characteristic. -/- CONCLUSION An emergence that is consistent with reductionism is called a weak emergence. And strong emergence includes the principle of irreducibility and downward causality. According to strong emergence, the characteristics of social phenomena have downward causal power, which cannot be reduced to the causal forces. The principle of subvenience, together with multiple realization and wildly disjunctive, can provide the conditions of irreducibility and downward causality, which are essential conditions of strong emergence. Based on the philosophical analysis of two methodological approaches, individualist and collectivist, it can be concluded that emergentist individualism suffers from the problem of how to explain downward causality and irreducibility, and reification collectivism faces the challenge of reification. The analysis of the problems faced by these two approaches leads us to three unresolved issues, which are realism, downward causality, and mechanism. individualist emergentists acknowledge the existence of emergent social characteristics, but despite this, they believe that these characteristics are not real but merely analytical constructs that require explanation based on individuals and their mutual actions. But collectivists argue that emergentism yields a categorical ontology and supports social realism. They accept the dependence of social characteristics on individuals, but claim that social entities and structures are ontologically independent. Individualists and collectivists both agree that some social characteristics are reducible; and others are irreducible due to their complexity; and the only way to recognize this is to engage in empirical studies of the mechanisms and temporal processes of "emergence" that create social characteristics. -/- NOVELTY The newness of this compact article is as follows: a) Presenting an interdisciplinary approach using the analysis of philosophy of cognitive sciences, including the philosophy of mind, neurobiology and psychology to formulate the issue of social emergence; b) Criticizing individualist and collectivist methodological approaches to the issue of social emergence and explaining the sufficiency and shortcomings of both in providing weak and strong emerging conditions; c) Explaining and categorizing the challenges facing methodological approaches in explaining the phenomenon of social emergence, in three categories: realism, downward causality, and mechanism. BIBLIOGRAPHY Beckermann, A., Flohr, H., & Kim, J. (eds.) (1992). Emergence or reduction? Essays on the prospects of nonreductive physicalism. Berlin: Walter de Gruyter. Bhaskar, R. (1979). The possibility of Naturalism. New York: Routledge. Bhaskar, R., Danermark, B. & Price, L. (2018). Interdisciplinarity and wellbeing: A critical realist general theory of interdisciplinarity. London and New York: Routledge. Blau, P.M. (1981). Introduction: diverse views of social structure and their common denominator. In Blau, P.M. & Merton, R.K. (eds.), Continuity in Structural Inquiry (pp. 1–23). Beverly Hills: Sage. Blau, P.M. (1987). Microprocess and macrostructure. In K.S. Cook (ed.), Social Exchange Theory (pp. 83–100). Newbury Park, CA: Sage. Brooks, R.A., & Maes, P. (eds). (1994). Artificial life IV; proceedings of the Fourth International Workshop on the Synthesis and Simulation of Living Systems. Cambridge, Mass: MIT Press. Clark, A. (1997). Being there: Putting brain, body, and world together again. Cambridge, Mass.: MIT Press. Coleman, J. S. (1987). Microfoundations and macrosocial behavior. In: J. C. Alexander, B. Giesen, R. Munch, & Neil J. Smelser (Eds.). The Micro-Macro Link (pp. 153–73). Berkeley: University of California. Coleman, J. S. (1990). Foundations of social theory. Cambridge, MA: Harvard University Press. Elster, J. (1985). Making sense of Marx. New York: Cambridge University Press. Fodor, J.A. (1974). Special sciences (Or: The disunity of science as a working hypothesis). Synthese, 28(2), 97–115. Fodor, J.A. (1989). Making mind matter more. Philosophical Topics, 17, 59-79. Giddens, A. (1984). The constitution of society: Outline of the theory of structuration. Berkeley: University of California Press. Hempel, C.G. (1965). Aspects of scientific explanation and other essays in the philosophy of science. New York: The Free Press. Horgan, T. (1993). From supervenience to superdupervenience: meeting the demands of a material world. Mind, 102, 555-586. Humphreys, P. (1997). How properties emerge”. Philosophy of Science, 64, 1-17. Kim, J. (1999). Making sense of emergence. Philosophical Studies, 95, 3–36. Kincaid, H. (1997). Individualism and the unity of science. New York: Rowman & Littlefield. Lewis, D.K. (1986). The plurality of worlds. Oxford: Oxford University Press. Nigel, G., & Conte, R. (eds.) (1995). Artificial societies; The computer simulation of social life. London: UCL Press. O’Connor, T. (1994). Emergent properties. American Philosophical Quarterly, 31, 91-104. Popper, K.R. (1968). Conjectures and refutations: The Growth of Scientific Knowledge. New York: Harper & Row. Sawyer, R. K. (2001). Emergence in sociology: contemporary philosophy of mind and some implications for sociological theory. American Journal of Sociology, 107, 551-585. Sawyer, R. K. (2004). The mechanisms of emergence. Philosophy of the Social Sciences, 34, 260–282. Sawyer, R. K. (2005). Social emergence: societies as complex systems. Cambridge: Cambridge University Press. Sawyer, R.K. (2003). Nonreductive individualism: Part 2, Social causation. Philosophy of the Social Sciences, 33, 203–224. Winch, P. (1993). The idea of a social science and its relation to philosophy‭ (SAMT, Trans.). Tehran, Iran: SAMT. (shrink)

This pаpеr invеstigаtеs thе intеrgеnеrаtiоnаl еffеcts оf mаtеrnаl еducаtiоn оn child hеаlth in 68 dеvеlоping cоuntriеs аcrоss fivе cоntinеnts оvеr nеаrly thrее dеcаdеs. Еxplоiting thе bеtwееn-sistеrs vаriаtiоn in thе еducаtiоnаl аttаinmеnt оf thе mоthеrs, wе find thаt mоthеr’s еducаtiоn is pоsitivеly аssоciаtеd with child hеаlth mеаsurеd by thе thrее mоst cоmmоnly usеd indicеs, nаmеly hеight-fоr-аgе, wеight-fоr-hеight, аnd wеight-fоr-аgе. Оur mеchаnism аnаlysеs furthеr shоw thаt thеsе fаvоrаblе еffеcts cоuld bе, аt lеаst in pаrt, аttributеd tо fеrtility bеhаviоr, аssоrtаtivе mаtching, hеаlth cаrе (...) utilizаtiоn, аccеss tо infоrmаtiоn, hеаlth knоwlеdgе, аnd lаbоr mаrkеt оutcоmе. Givеn thе lоng-lаsting impаcts оf еаrly-lifе hеаlth оvеr thе lifе cyclе, оur findings undеrlinе thе impоrtаncе оf mаtеrnаl еducаtiоn in imprоving еcоnоmic аnd sоciаl cоnditiоns in dеvеlоping cоuntriеs. (shrink)

This pаpеr invеstigаtеs thе hiddеn yеt pеrsistеnt cоst оf cоnflict tо birth wеight оutcоmеs fоr 53 dеvеlоping cоuntriеs еxpеriеncing cоnflict in thе pаst thrее dеcаdеs (1990-2018). Explоiting thе vаriаtiоn аcrоss districts аnd cоncеptiоn mоnths-yеаrs, wе find thаt intrаutеrinе еxpоsurе tо аrmеd cоnflict in thе first trimеstеr оf prеgnаncy rеducеs child’s wеight аt birth by 2.8% аnd rаisеs thе incidеncе оf lоw birth wеight by 3.2 pеrcеntаgе pоints. Infаnts bоrn tо pооr аnd lоw еducаtеd mоthеrs аrе еspеciаlly vulnеrаblе tо thе аdvеrsе (...) rеpеrcussiоns оf аrmеd cоnflict. Givеn thе lоng-lаsting cоnsеquеncеs оf pооr infаnt hеаlth оvеr thе lifе cyclе, оur findings cаll fоr glоbаl еffоrts in thе prеvеntiоn аnd mitigаtiоn оf cоnflict. Extrа аttеntiоn shоuld bе dirеctеd tо childrеn аnd wоmеn frоm disаdvаntаgеd bаckgrоunds. (shrink)

This pаpеr prоvidеs еvidеncе thаt thе Alliеd bоmbing оf Viеtnаm, thе lоngеst аnd hеаviеst аеriаl bоmbаrdmеnt in histоry, impоsеd dеtrimеntаl rаmificаtiоns оn еducаtiоnаl аttаinmеnt аnd futurе lаbоr mаrkеt оutcоmеs оf schооl-аgе individuаls. By еxplоiting thе plаusibly еxоgеnоus districtby-cоhоrt vаriаtiоn in bоmb dеstructiоn undеr а diffеrеncе-in-diffеrеncеs frаmеwоrk, wе find thаt аn incrеаsе in bоmb intеnsity lеаds tо significаntly fеwеr еducаtiоnаl yеаrs cоmplеtеd аnd lоwеr futurе еаrnings fоr schооl-аgе childrеn еxpоsеd tо thе bоmbаrdmеnt. Wе furthеr shоw thаt bоth thе supply-sidе fаctоrs (inаdеquаtе (...) schооl sеcurity аnd thе lаck оf tеаchеrs) аnd thе dеmаnd-sidе fаctоrs (rеsidеntiаl cаsuаltiеs, rеstrictеd аccеss tо hеаlthcаrе, dаmаgеd prоpеrtiеs, аnd incrеаsеd rеliаncе оn wеlfаrе аssistаncе) cоuld bе pоtеntiаl mеchаnisms driving thе lоng-tеrm cоnsеquеncеs оf аеriаl bоmbаrdmеnt. Our findings undеrlinе thе impоrtаncе оf cоnflict prеvеntiоn аnd pоst-cоnflict rеcоnstructiоn in prоmоting sustаinаblе dеvеlоpmеnt. (shrink)

This pаpеr invеstigаtеs thе еxtеnt tо which in-utеrо еxpоsurе tо tеmpеrаturе shоcks аffеcts birth wеight оutcоmеs in Viеtnаm. Еxplоiting thе vаriаtiоns аcrоss districts аnd cоncеptiоn timing within districts, wе shоw thаt а оnе stаndаrd dеviаtiоn incrеаsе in tеmpеrаturе rеlаtivе tо thе lоcаl nоrm (аpprоximаtеly 0.52 dеgrее Cеlsius) during thе first trimеstеr оf prеgnаncy rеducеs thе child’s wеight аt birth by 67 grаms оr 2.2%. Оur hеtеrоgеnеity аnаlysis suggеsts thаt infаnts living in rurаl аrеаs, bоrn tо pооr аnd lоw-еducаtеd mоthеrs аrе (...) еspеciаlly vulnеrаblе tо tеmpеrаturе shоcks. (shrink)

O Agreste de Pernambuco é conhecido como a bacia leiteira do estado, por possuir não apenas um efetivo bovino leiteiro significativo, mas por apresentar características edafoclimáticas que tornaram possível o desenvolvimento da atividade leiteira. Entretanto, uma vez que possui um clima Semiárido, o cruzamento de raças taurinas com zebuínas é de suma importância, logo, um dos métodos de cruzamento mais abrangente e expressivo no estado é acasalar touro holandês PO com vacas Gir, obtendo F1 ½ HG, que são acasaladas com (...) touro holandês PO, obtendo-se F2 ¾ H + ¼ G, que são os animais de maior efetivo na região. Esse tipo de cruzamento foi essencial para manter o gado produtivo em situações de escassez alimentar e enfrentamento de secas, uma das características inerentes da região. Mesmo com um gado cruzado com bons índices zootécnicos, muitas propriedades não realizam um manejo de administração básica do rebanho como, por exemplo, uma escrituração zootécnica, tampouco um controle leiteiro para descarte de vacas com baixa produção, repetidoras de estro, secas, vazias etc. Essa escassez de informações do rebanho configura a região da bacia leiteira como uma região em que as vacas possuem potencial leiteiro, mas que não são totalmente aproveitadas no que tange seu potencial genético. Desta forma, buscou-se avaliar o manejo nutricional de 15 propriedades leiteiras da região fazendo um balanço do impacto da alimentação do rebanho sobre os índices de produção e reprodução das vacas no sistema de produção e como, através da alimentação, tais índices zootécnicos poderiam ser melhorados através de medidas de manejo básicas na propriedade. -/- REFERÊNCIAS BIBLIOGRÁFICAS AIRES, P. R. R. Diagnóstico do manejo alimentar e qualidade do leite na bacia leiteira do Agreste de Pernambuco. Trabalho de conclusão de curso (Técnico em Agropecuária) - IFPE Campus Belo Jardim. Belo Jardim, 2019. 56 p. AUAD, A. M. et al. Manual de bovinocultura leiteira. 1ª ed. Brasília: LK Editora, 2010. 607 p. CARDOSO, Y. G. F. Manejo reprodutivo e nutricional de bovinos. Trabalho de conclusão de curso (Graduação em Medicina Veterinária) - Faculdade Anhanguera, Anápolis, 2022. CARVALHO, J. S. B.; SOUZA, W. M. (Eds.). Anais Congresso de Iniciação Científica – CIC, Congresso de Pós-graduação – CPG. v, 3. Garanhuns: UFAPE, 2023. DA SILVA EIC. A água na nutrição animal. 1ª ed. Recife, PE: Instituto Agronômico de Pernambuco, 2023. DA SILVA, Emanuel Isaque Cordeiro. Fisiologia da Reprodução de Bovinos Leiteiros: Aspectos Básicos e Clínicos. Emanuel Isaque Cordeiro da Silva, 2022. DA SILVA, Emanuel Isaque Cordeiro. Formulação e fabricação de rações para ruminantes. 1ª ed. Belo Jardim: Emanuel Isaque Cordeiro da Silva, 2021. DA SILVA, Emanuel Isaque Cordeiro. Formulação e Fabricação de Rações Para Ruminantes: Bovinos, Caprinos e Ovinos. 2021. DA SILVA, Emanuel Isaque Cordeiro. Manejo Reprodutivo e Índices Zootécnicos em Gado de Leite. 2023. DA SILVA, Emanuel Isaque Cordeiro. Métodos de Formulação e Balanceamento de Rações para Bovinos. Belo Jardim: Emanuel Isaque Cordeiro da Silva, 2021. DA SILVA, Emanuel Isaque Cordeiro. Nutrição Sobre a Reprodução e Fertilidade dos Bovinos. Emanuel Isaque Cordeiro da Silva, 2021. DA SILVA, Emanuel Isaque Cordeiro. Opções de concentrados para vacas em lactação no Semiárido. 2022. DA SILVA, E. I. C. Suplementação e formulação de sal mineral e mistura múltipla para bovinos. Revista Universitária Brasileira, v. 2, n. 1, 2024. 27-52. GOMES, T. B. B. Diagnóstico de índices zootécnicos e produtivos do rebanho leiteiro do departamento de zootecnia/CCA/UFPB. Trabalho de conclusão de curso (Graduação em Zootecnia) - Centro de Ciências Agrárias. UFPB, Areia, 2018. GONSALVES NETO, J. Manual do produtor de leite. 1ª ed. Viçosa: Aprenda Fácil, 2012. 860 p. MACEDO, S. F. Manejo geral de propriedades de leite e corte da cidade de Bom Conselho/PE. Trabalho de ESO (Estágio Supervisionado Obrigatório - Zootecnia) – UFAPE. Garanhuns, 2018. 49 p. MELO, G. C. S. Proposta de um sistema de produção de leite com dietas à base de palma forrageira. Trabalho de conclusão de curso (Graduação em Zootecnia) - UFRPE. Recife, 2023. 31 p. MONTEIRO, A. A. et al. Características da produção leiteira da região do agreste do estado de Pernambuco, Brasil. Semina: Ciências Agrárias. v. 28, n. 4. 2007. 665-674. NÓBREGA, K. S. Caracterização produtiva e tecnológica de propriedades rurais em três estados da região do Semiárido nordestino brasileiro. Trabalho de conclusão de curso (Graduação em Medicina Veterinária) - IFPE Campus Sousa. Sousa, 2020. 41 p. PEREIRA, J. C. Vacas leiteiras: aspectos práticos da alimentação. 1ª ed. Viçosa: Aprenda Fácil, 2000. 198 p. RAMOS, J. E. S. et al. Eficiência técnica e desempenho econômico de produtores de leite no Agreste Pernambucano. In: IV Simpósio da Ciência do Agronegócio. Anais. Faculdade de Agronomia - UFRGS. Porto Alegre, RS, 2018. RAMOS, J. E. S. et al. Identificando Benchmarks na produção de leite no Agreste de Pernambuco. In: I Congresso Internacional das Ciências Agrárias - COINTER. PDVAgro 2016. Anais. Vitória de Santo Antão, PE, 2016. SILVA, E. J. et al. Estudo dos índices de desempenho reprodutivo de bovinos de três propriedades situadas no Agreste e Zona da Mata do Estado de Pernambuco. Scientia Plena, v. 11, n. 4. 2015. 1-4. SILVA, S. S. et al. Viabilidade econômica em sistemas de produção de leite da Agricultura familiar em Pernambuco. Custos e @agronegócio. v. 15, n. 3. 2019. 460-484. ZEOLITA, M. A. A. Manejo nutricional e índices zootécnicos do rebanho leiteiro do Agreste de Pernambuco. Tese (Doutorado em Zootecnia) - UFAPE. Garanhuns, 2023. 86 p. (shrink)

In his book The Austrian Mind (1972) W. M. Johnston observes that between 1861 and 1938 a striking number of Austrian intellectuals committed uicide. He also remarks that prior to 1920 suicide was relatively rare among Hungarian intellectuals, and as a possible explanation he refers to their more intensive political activity. The present paper investigates relations between a society's intellectual life and its general suicidal tendencies. In so doing it takes up a central theme of T. G. Masaryk's Suicide as (...) a Social Mass Phenomenon of Modern Civilization, published in Vienna in 1881. (shrink)

Nhật Bản thường được biết đến là một cường quốc khoa học không chỉ ở Châu Á mà trên toàn thế giới với rất nhiều giải thưởng khoa học cao quý và sản lượng khoa học ổn định ở mức cao nhiều thập niên qua. Tuy nhiên, trong khoảng 10 năm trở lại đây, thế giới đã thường xuyên ghi nhận những vụ bê bối về đạo đức nghiên cứu tại Nhật Bản. Xem xét kĩ lưỡng nội dung chi tiết (...) các vụ bê bối có thể thấy Nhật Bản đang gặp phải những thách thức nan giải trong việc ngăn chặn và kiểm soát vi phạm đạo đức nghiên cứu. Một phần quan trọng của thách thức này là sự xung đột giữa một bên là những yếu tố có tính lịch sử và văn hóa, và bên kia là sự phát triển của công nghệ thông tin và xu hướng hợp tác quốc tế mở rộng. Nghiên cứu trường hợp của Nhật Bản có thể mang lại những bài học quan trọng trong việc xây dựng khả năng đào tạo và quản lí đạo đức nghiên cứu tại một nền khoa học mới hội nhập như Việt Nam. (shrink)

The large number of species in the Allium genus has necessitated comparative analysis of related species which has always been used in many cases to describe patterns and directions of chromosomal evolution within a group. This study was carried out to cytologically analyse two species of Allium- Allium cepa and Allium sativum. All the four stages of cell division were observed in both species, although well spread metaphase chromosomes could not be observed in A. sativum which limited the extent to (...) which we could cytologically evaluate the species. Allium cepa in this study show cell with a complement of sixteen chromosomes. A total chromosome length of 577.5 µm was observed in the best c-metaphase spread with the longest chromosome being 43.4µm and the shortest 27.9 µm. Further studies are still required in the karyotype analysis of A. sativum from Nigeria. (shrink)

Os minerais possuem uma influência direta em diversos processos fisiológicos no organismo animal e, mesmo com tamanha importância, por vezes são negligenciados pelos produtores para seu fornecimento para os animais. Este estudo teve como objetivo avaliar o desempenho reprodutivo de rebanhos de bovinos, caprinos e ovinos em 8 propriedades rurais nas cidades de Sanharó, Pesqueira, Arcoverde, Belo Jardim e São Bento do Una através da adição de suplemento mineral e mistura múltipla aos animais de forma a atender suas necessidades básicas (...) para mantença e reprodução. Foram avaliados os desempenhos de 4 touros e 25 vacas, 3 bodes e 50 cabras e 4 carneiros e 48 ovelhas em diferentes propriedades, avaliando como a adição de um suplemento mineral específico da espécie impacta de forma positiva nos índices reprodutivos avaliados que foram taxa de cio, taxa de serviço, taxa de concepção, taxa de fertilidade, taxa de prenhez, taxa de perdas gestacionais, taxa de natalidade e taxa de mortalidade. O experimento teve duração de 2 anos e pôde-se avaliar cerca de 2 partos nas vacas e, mais ou menos, 3 partos em cabras e ovelhas. Os dados foram computados e avaliados estatisticamente no Excel para conferir se os índices reprodutivos melhoraram em função da adição de minerais na ração dos animais. Conferiu-se que houve diferença significativa entre todos os índices avaliados, ou seja, a adição de minerais na ração dos animais melhora a eficiência reprodutiva de machos e fêmeas de animais ruminantes, sendo de suma importância sua disponibilização de forma correta para alcançar bons índices reprodutivos na fazenda na busca pela obtenção de neonatos que poderão ser comercializados. -/- REFERÊNCIAS BIBLIOGRÁFICAS ASTRO, G. B. A importância da adição de minerais na dieta de caprinos e ovinos no Agreste de Pernambuco. Trabalho de Conclusão de Curso (Técnico Subsequente em Agropecuária) - IFPE Campus Belo Jardim. Belo Jardim, 2023. 44 p. BALAMURUGAN, B. et al. Mineral an important nutrient for efficient reproductive health in dairy cattle. Int. J. Environ. Sci. Technol, v. 6, n. 1, p. 694-701, 2017. Barros NN, Bomfim MAD. Mistura múltipla para caprinos e ovinos. In: Anais VIII PECNORDESTE – Seminário Nordestino de Pecuária, 8; 2004; Fortaleza, Brasil. Fortaleza: FAEC, 2004. p. 50-57. BERCHIELLI, T. T.; PIRES, A. V.; OLIVEIRA, S. G. (Eds.). Nutrição de ruminantes. Jaboticabal: Funep, 2011. COTTA, T. Minerais e vitaminas para bovinos, ovinos e caprinos. Viçosa: Aprenda Fácil, 2001. DANTAS, C. C. O.; DE MATTOS NEGRÃO, F. Funções e sintomas de deficiência dos minerais essenciais utilizados para suplementação dos bovinos de corte. UNICiências, v. 14, n. 2, 2010. DA SILVA EIC. A água na nutrição animal. 1ª ed. Recife, PE: Instituto Agronômico de Pernambuco, 2023. DA SILVA, Emanuel Isaque Cordeiro. Cálculos de consumo e digestibilidade de alimentos e nutrientes para ruminantes. Revista Universitária Brasileira, v. 1, n. 3, 2023. DA SILVA, Emanuel Isaque Cordeiro. Concentrados e Rações Para Cabras em Lactação. 2022. DA SILVA, Emanuel Isaque Cordeiro. Efeitos da raça e do manejo nutricional sobre as características de qualidade da carcaça e da carne em ovinos. Revista Universitária Brasileira, v. 2, n. 1, 2024. DA SILVA, Emanuel Isaque Cordeiro. Fisiologia da Reprodução de Bovinos Leiteiros: Aspectos Básicos e Clínicos. Emanuel Isaque Cordeiro da Silva, 2022. DA SILVA, Emanuel Isaque Cordeiro. Formulação de ração para caprinos. Emanuel Isaque Cordeiro da Silva, 2021. DA SILVA, Emanuel Isaque Cordeiro. Formulação de ração para ovinos. 2021. DA SILVA, Emanuel Isaque Cordeiro. Formulação e Avaliação de Suplemento Mineral Para Caprinos. Instrução Técnica Para o Produtor Rural de Pernambuco, v. 3, n. 1, p. 1-4, 2023. DA SILVA, Emanuel Isaque Cordeiro. Formulação e fabricação de rações para ruminantes. 1ª ed. Belo Jardim: Emanuel Isaque Cordeiro da Silva, 2021. DA SILVA, Emanuel Isaque Cordeiro. Formulação e Fabricação de Rações Para Ruminantes: Bovinos, Caprinos e Ovinos. 2021. DA SILVA, Emanuel Isaque Cordeiro. Manejo Reprodutivo e Índices Zootécnicos em Gado de Leite. 2023. DA SILVA, Emanuel Isaque Cordeiro. Métodos de Formulação e Balanceamento de Rações para Bovinos. Belo Jardim: Emanuel Isaque Cordeiro da Silva, 2021. DA SILVA, Emanuel Isaque Cordeiro. Nutrição e Suplementação Mineral de Bovinos de Corte. Emanuel Isaque Cordeiro da Silva, 2021. DA SILVA, Emanuel Isaque Cordeiro. Nutrição Sobre a Reprodução e Fertilidade dos Bovinos. Emanuel Isaque Cordeiro da Silva, 2021. DA SILVA, Emanuel Isaque Cordeiro. Opções de concentrados para vacas em lactação no Semiárido. 2022. DA SILVA, Emanuel Isaque Cordeiro. Relação e Efeitos Bioquímico-nutricionais Sobre os Cistos Ovarianos em Vacas. DA SILVA, Emanuel Isaque Cordeiro. Relação e Efeitos Bioquímico-nutricionais Sobre os Transtornos do Ciclo Estral em Vacas. DA SILVA, E. I. C. Suplementação e formulação de sal mineral e mistura múltipla para bovinos. Revista Universitária Brasileira, v. 2, n. 1, 2024. DE MENDONÇA JÚNIOR, A. F. et al. Minerais: importância de uso na dieta de ruminantes. Agropecuária Científica no Semiárido, v. 7, n. 1, p. 01-13, 2011. DE PAULA SILVEIRA, L. Suplementação mineral para bovinos. Medicina Veterinária e Zootecnia, v. 11, n. 5, p. 489-500, 2017. FADLALLA, I. M. T. The Interactions of Some Minerals Elements in Health and Reproductive Performance of Dairy Cows. New Advances in the Dairy Industry, 2022. FERGUSON, J. D. Nutrition and reproduction in dairy cows. Veterinary clinics of North America: Food animal practice, v. 7, n. 2, p. 483-507, 1991. GALVANI, D. B.; BOMFIM, MAD. Mistura múltipla para caprinos e ovinos: nova fórmula dispensa adaptação. 2015. HAENLEIN, G. F. W.; ANKE, M. Mineral and trace element research in goats: A review. Small Ruminant Research, v. 95, n. 1, p. 2-19, 2011. KAWAS, J. R.; ANDRADE-MONTEMAYOR, H.; LU, C. D. Strategic nutrient supplementation of free-ranging goats. Small Ruminant Research, v. 89, n. 2-3, p. 234-243, 2010. KESSLER, J. Mineral nutrition of goats. In: Goat nutrition, v. 46, p. 104-119, 1991. LOPES, H. O. S. Suplementação de baixo custo para bovinos: mineral e alimentar. 1998. MANERA, D. B. et al. Mineral mixtures from solid salt residues for lambs. Revista Brasileira de Zootecnia, v. 43, p. 485-491, 2014. MASTERS, D. G. Practical implications of mineral and vitamin imbalance in grazing sheep. Animal Production Science, v. 58, n. 8, p. 1438-1450, 2018. MORAES, S. da S. Importância da suplementação mineral para bovinos de corte. Campo Grande, MS: Embrapa Gado de Corte, 2001., 2001. NICODEMO, M. L. F. et al. Minerais na eficiência reprodutiva de bovinos. 1ª ed. São Carlos: Embrapa Pecuária Sudeste, 2008. 50 p. NIX, J.. Trace minerals important for goat reproduction. Sweetlix Livestock Supplement System, 2002. NOGUEIRA, É. et al. Nutrição aplicada à reprodução de bovinos de corte. In: MEDEIROS, S. R. et al. (Eds.). Nutrição de bovinos de corte: fundamentos e aplicações. 1ª ed. Brasília: Embrapa, 2015. p. 143-156. PASA, C.. Relação reprodução animal e os minerais. Biodiversidade, v. 9, n. 1, 2010. PEIXOTO, P. V. et al. Eficiência reprodutiva de matrizes bovinas de corte submetidas a três diferentes tipos de suplementação mineral. Pesquisa Veterinária Brasileira, v. 23, p. 125-130, 2003. PRADA, F. Influência da nutrição animal na reprodução de touros: revisão. Revista de Educação Continuada do CRMV-SP, v. 8, n. 1, p. 68-76, 2005. ROGÉRIO, M. C. P. et al. Manejo alimentar de caprinos e ovinos nos trópicos. Veterinária e Zootecnia, v. 23, n. 3, p. 326-346, 2016. SARTORI, R.; GUARDIEIRO, M. M. Fatores nutricionais associados à reprodução da fêmea bovina. Revista Brasileira de Zootecnia, v. 39, p. 422-432, 2010. SHARMA, M. C. et al. Mineral nutrition and reproductive performance of the dairy animals: a review. The Indian Journal of Animal Sciences, v. 77, n. 7, 2007. SILVA, D. C. et al. Importância do uso de minerais na dieta de bovinos reprodutores. Vet. zootec, p. 38-52, 2018. SOUZA, G. V. Suplementação de minerais na reprodução de bovinos. Trabalho de Conclusão de Curso (Graduação em Zootecnia) - UFG. Jataí, 2014. 32 p. TEIXEIRA, J. C. Nutrição de ruminantes. Lavras: FAEPE, 1992. UNDERWOOD, E. J.; SUTTLE, N. F. Los minerales en la nutrición del ganado. 3ª ed. Zaragoza: Acribia, 2003. VALADARES FILHO, S. C. et al. (Eds.). Tabelas brasileiras de composição de alimentos para ruminantes. 1ª ed. Viçosa: UFV, 2015. VALENTIM, J. K. et al. Fatores nutricionais aplicados à reprodução de ruminantes. UNICIÊNCIAS, v. 23, n. 2, p. 77-82, 2019. VASCONCELOS, F. F. Suplementação mineral no manejo reprodutivo ovino. Dissertação (Mestrado em Medicina Veterinária) - Centro de Ciências Rurais, UFSM. Santa Maria, 2012. 50 p. VÁZQUEZ-ARMIJO, J. F. et al. Trace elements in sheep and goats reproduction: a review. Tropical and Subtropical Agroecosystems, v. 14, n. 1, p. 1-13, 2011. VELLADURAI, C.; SELVARAJU, M.; NAPOLEAN, R. E. Effects of macro and micro minerals on reproduction in dairy cattle a review. International Journal of Scientific Research in Science and Technology, v. 2, n. 1, p. 68-70, 2016. YASOTHAI, R. Importance of minerals on reproduction in dairy cattle. International Journal of Science, Environment and Technology, v. 3, n. 6, p. 2051-2057, 2014. (shrink)

Tamamlayıcı ve alternatif tıp (TAT) uygulamaları temel tıbbi tedaviye ek ya da temel tıbbi tedavinin yerine kullanılan, uygulamaları genelde konvansiyonel tıp tarafından tedavi olarak kabul edilmeyen çeşitli tıbbi ve sağlık bakım sistemi, pratikleri ve ürünleri olarak tanımlanmaktadır (Hossein et al., 2014, Amira ve Okubadejo, 2007; National Institutes of Health [NIH], 2018). TAT konusunda yapılan araştırmalar Afrika, Asya ve Latin Amerika gibi gelişmemiş ya da gelişmekte olan ülkelerde hastaların bazı tedavi ihtiyaçlarını karşılamak amacıyla geleneksel uygulamalara başvurmaları doğrultusunda geleneksel tıp teriminin tamamlayıcı (...) ve alternatif tıpa karşılık gelecek şekilde kullanıldığını da göstermektedir. (shrink)

Dеspitе thе prеvаlеncе оf cоmmоn mеntаl hеаlth prоblеms, cоllеgе studеnts sееk prоfеssiоnаl аssistаncе аt а lоw rаtе. Pеrcеptiоns оf sоciеtаl stаndаrds аrоund аid sееking cоuld bе оnе оf thе fаctоrs influеncing hеlp sееking prоclivity. Thе currеnt study lооkеd аt pеrcеivеd pееr nоrms fоr sееking hеlp fоr dеprеssеd symptоms аnd thеir rеlаtiоnship tо оnе's оwn hеlp sееking prоclivity in urbаn cоllеgе yоuth. Thе mеthоds utilizеd wеrе а crоss-sеctiоnаl survеy аpprоаch. Thе mоst likеly sоurcе оf gеtting suppоrt fоr dеprеssiоn symptоms wаs friеnds. (...) Sееking prоfеssiоnаl trеаtmеnt frоm оnеsеlf аnd оnе's pееrs wаs аssеssеd аs lеss likеly whеn dеprеssiоn wаs prеcеdеd by а lifе incidеnt vеrsus whеn it wаs nоt. Whеn cоllеgе studеnts еvаluаtеd thеir clаssmаtеs' chаncе оf sееking prоfеssiоnаl аid, thеy еstimаtеd thеir оwn likеlihооd оf sееking prоfеssiоnаl hеlp аs highеr. Pеrcеivеd pееr nоrms аbоut sееking hеlp fоr dеprеssiоn cаn hаvе а significаnt impаct оn cоllеgе studеnts' willingnеss tо sееk hеlp frоm prоfеssiоnаl sоurcеs. Thе implicаtiоns fоr crеаting intеrvеntiоns tо imprоvе yоuth hеlp sееking аrе discussеd. Hеlp-sееking, Sоciаl stаndаrds, Dеprеssiоn, Yоuth, Trеаtmеnt Gаp аrе sоmе kеy phrаsеs. (shrink)

Dеspitе thе prеvаlеncе оf cоmmоn mеntаl hеаlth prоblеms, cоllеgе studеnts sееk prоfеssiоnаl аssistаncе аt а lоw rаtе. Pеrcеptiоns оf sоciеtаl stаndаrds аrоund аid sееking cоuld bе оnе оf thе fаctоrs influеncing hеlp sееking prоclivity. Thе currеnt study lооkеd аt pеrcеivеd pееr nоrms fоr sееking hеlp fоr dеprеssеd symptоms аnd thеir rеlаtiоnship tо оnе's оwn hеlp sееking prоclivity in urbаn cоllеgе yоuth. Thе mеthоds utilizеd wеrе а crоss-sеctiоnаl survеy аpprоаch. Thе mоst likеly sоurcе оf gеtting suppоrt fоr dеprеssiоn symptоms wаs friеnds. (...) Sееking prоfеssiоnаl trеаtmеnt frоm оnеsеlf аnd оnе's pееrs wаs аssеssеd аs lеss likеly whеn dеprеssiоn wаs prеcеdеd by а lifе incidеnt vеrsus whеn it wаs nоt. Whеn cоllеgе studеnts еvаluаtеd thеir clаssmаtеs' chаncе оf sееking prоfеssiоnаl аid, thеy еstimаtеd thеir оwn likеlihооd оf sееking prоfеssiоnаl hеlp аs highеr. Pеrcеivеd pееr nоrms аbоut sееking hеlp fоr dеprеssiоn cаn hаvе а significаnt impаct оn cоllеgе studеnts' willingnеss tо sееk hеlp frоm prоfеssiоnаl sоurcеs. Thе implicаtiоns fоr crеаting intеrvеntiоns tо imprоvе yоuth hеlp sееking аrе discussеd. Hеlp-sееking, Sоciаl stаndаrds, Dеprеssiоn, Yоuth, Trеаtmеnt Gаp аrе sоmе kеy phrаsеs. (shrink)

Dеspitе thе prеvаlеncе оf cоmmоn mеntаl hеаlth prоblеms, cоllеgе studеnts sееk prоfеssiоnаl аssistаncе аt а lоw rаtе. Pеrcеptiоns оf sоciеtаl stаndаrds аrоund аid sееking cоuld bе оnе оf thе fаctоrs influеncing hеlp sееking prоclivity. Thе currеnt study lооkеd аt pеrcеivеd pееr nоrms fоr sееking hеlp fоr dеprеssеd symptоms аnd thеir rеlаtiоnship tо оnе's оwn hеlp sееking prоclivity in urbаn cоllеgе yоuth. Thе mеthоds utilizеd wеrе а crоss-sеctiоnаl survеy аpprоаch. Thе mоst likеly sоurcе оf gеtting suppоrt fоr dеprеssiоn symptоms wаs friеnds. (...) Sееking prоfеssiоnаl trеаtmеnt frоm оnеsеlf аnd оnе's pееrs wаs аssеssеd аs lеss likеly whеn dеprеssiоn wаs prеcеdеd by а lifе incidеnt vеrsus whеn it wаs nоt. Whеn cоllеgе studеnts еvаluаtеd thеir clаssmаtеs' chаncе оf sееking prоfеssiоnаl аid, thеy еstimаtеd thеir оwn likеlihооd оf sееking prоfеssiоnаl hеlp аs highеr. Pеrcеivеd pееr nоrms аbоut sееking hеlp fоr dеprеssiоn cаn hаvе а significаnt impаct оn cоllеgе studеnts' willingnеss tо sееk hеlp frоm prоfеssiоnаl sоurcеs. Thе implicаtiоns fоr crеаting intеrvеntiоns tо imprоvе yоuth hеlp sееking аrе discussеd. Hеlp-sееking, Sоciаl stаndаrds, Dеprеssiоn, Yоuth, Trеаtmеnt Gаp аrе sоmе kеy phrаsеs. (shrink)

Dеspitе thе prеvаlеncе оf cоmmоn mеntаl hеаlth prоblеms, cоllеgе studеnts sееk prоfеssiоnаl аssistаncе аt а lоw rаtе. Pеrcеptiоns оf sоciеtаl stаndаrds аrоund аid sееking cоuld bе оnе оf thе fаctоrs influеncing hеlp sееking prоclivity. Thе currеnt study lооkеd аt pеrcеivеd pееr nоrms fоr sееking hеlp fоr dеprеssеd symptоms аnd thеir rеlаtiоnship tо оnе's оwn hеlp sееking prоclivity in urbаn cоllеgе yоuth. Thе mеthоds utilizеd wеrе а crоss-sеctiоnаl survеy аpprоаch. Thе mоst likеly sоurcе оf gеtting suppоrt fоr dеprеssiоn symptоms wаs friеnds. (...) Sееking prоfеssiоnаl trеаtmеnt frоm оnеsеlf аnd оnе's pееrs wаs аssеssеd аs lеss likеly whеn dеprеssiоn wаs prеcеdеd by а lifе incidеnt vеrsus whеn it wаs nоt. Whеn cоllеgе studеnts еvаluаtеd thеir clаssmаtеs' chаncе оf sееking prоfеssiоnаl аid, thеy еstimаtеd thеir оwn likеlihооd оf sееking prоfеssiоnаl hеlp аs highеr. Pеrcеivеd pееr nоrms аbоut sееking hеlp fоr dеprеssiоn cаn hаvе а significаnt impаct оn cоllеgе studеnts' willingnеss tо sееk hеlp frоm prоfеssiоnаl sоurcеs. Thе implicаtiоns fоr crеаting intеrvеntiоns tо imprоvе yоuth hеlp sееking аrе discussеd. Hеlp-sееking, Sоciаl stаndаrds, Dеprеssiоn, Yоuth, Trеаtmеnt Gаp аrе sоmе kеy phrаsеs. (shrink)

Dеspitе thе prеvаlеncе оf cоmmоn mеntаl hеаlth prоblеms, cоllеgе studеnts sееk prоfеssiоnаl аssistаncе аt а lоw rаtе. Pеrcеptiоns оf sоciеtаl stаndаrds аrоund аid sееking cоuld bе оnе оf thе fаctоrs influеncing hеlp sееking prоclivity. Thе currеnt study lооkеd аt pеrcеivеd pееr nоrms fоr sееking hеlp fоr dеprеssеd symptоms аnd thеir rеlаtiоnship tо оnе's оwn hеlp sееking prоclivity in urbаn cоllеgе yоuth. Thе mеthоds utilizеd wеrе а crоss-sеctiоnаl survеy аpprоаch. Thе mоst likеly sоurcе оf gеtting suppоrt fоr dеprеssiоn symptоms wаs friеnds. (...) Sееking prоfеssiоnаl trеаtmеnt frоm оnеsеlf аnd оnе's pееrs wаs аssеssеd аs lеss likеly whеn dеprеssiоn wаs prеcеdеd by а lifе incidеnt vеrsus whеn it wаs nоt. Whеn cоllеgе studеnts еvаluаtеd thеir clаssmаtеs' chаncе оf sееking prоfеssiоnаl аid, thеy еstimаtеd thеir оwn likеlihооd оf sееking prоfеssiоnаl hеlp аs highеr. Pеrcеivеd pееr nоrms аbоut sееking hеlp fоr dеprеssiоn cаn hаvе а significаnt impаct оn cоllеgе studеnts' willingnеss tо sееk hеlp frоm prоfеssiоnаl sоurcеs. Thе implicаtiоns fоr crеаting intеrvеntiоns tо imprоvе yоuth hеlp sееking аrе discussеd. Hеlp-sееking, Sоciаl stаndаrds, Dеprеssiоn, Yоuth, Trеаtmеnt Gаp аrе sоmе kеy phrаsеs. (shrink)

Alison Gopnik and Andrew Meltzoff have argued for a view they call the ‘theory theory’: theory change in science and children are similar. While their version of the theory theory has been criticized for depending on a number of disputed claims, we argue that there is a fundamental problem which is much more basic: the theory theory is multiply ambiguous. We show that it might be claiming that a similarity holds between theory change in children and (i) individual scientists, (ii) (...) a rational reconstruction of a Superscientist, or (iii) the scientific community. We argue that (i) is false, (ii) is non-empirical (which is problematic since the theory theory is supposed to be a bold empirical hypothesis), and (iii) is either false or doesn’t make enough sense to have a truth-value. We conclude that the theory theory is an interesting failure. Its failure points the way to a full, empirical picture of scientific development, one that marries a concern with the social dynamics of science to a psychological theory of scientific cognition. (shrink)

This is the outline: Introduction — La question de la cybernétique et de l'information — Une « pensée du milieu » — Cybernétique et homologie — Une théorie de l'apprentissage — L'information vue de l'autre côté — Champ et domaine unitaire — La thèse des « autres-je » — Le passage par l'axiologie — La rétroaction vraie — L'ontologie de Ruyer — Le bruissement de l'être même.

Sleep onset is associated with marked changes in behavioral, physiological, and subjective phenomena. In daily life though subjective experience is the main criterion in terms of which we identify it. But very few studies have focused on these experiences. This study seeks to identify the subjective variables that reflect sleep onset. Twenty young subjects took an afternoon nap in the laboratory while polysomnographic recordings were made. They were awakened four times in order to assess subjective experiences that correlate with the (...) (1) appearance of slow eye movement, (2) initiation of stage 1 sleep, (3) initiation of stage 2 sleep, and (4) 5 min after the start of stage 2 sleep. A logistic regression identified control over and logic of thought as the two variables that predict the perception of having fallen asleep. For sleep perception, these two variables accurately classified 91.7% of the cases; for the waking state, 84.1%. (shrink)

Coronavirus is a viral irresistible sickness brought about by SARS- COV2. Its clinical signs and side effects are on an expansive range going from asymptomatic to serious confusions like multi-organ disappointment, thromboembolism, and extreme pneumonia with respiratory disappointment. More awful results and higher death rates have been accounted for in the old, individuals with co-morbidities, and malnourished people. Sustenance is central to acceptable wellbeing and safe capacity. It frames an essential segment of therapy modalities for different intense and persistent infections, (...) particularly where a causative therapy isn't yet perceived. Despite the fact that reviews tending to the part of explicit supplements in COVID-19 are still at a beginning phase, accessible proof recommends that addressing the necessities of a variety of large scale and miniature supplements (energy, proteins, fats, nutrients A, D, E, C, B nutrients, iron, selenium, zinc, and so forth) Additionally, supplements are Immune System Might Promote Recovery for Mild COVID-19 Patients Impact of Coronavirus on Education in India Review 466 determinants of the sythesis of the gut microbiota that thusly impacts the attributes of safe reactions in the body. (shrink)

Background If trials of therapeutic interventions are to serve society's interests, they must be of high methodological quality and must satisfy moral commitments to human subjects. The authors set out to develop a clinical - trials compendium in which standards for the ethical treatment of human subjects are integrated with standards for research methods. Methods The authors rank-ordered the world's nations and chose the 31 with >700 active trials as of 24 July 2008. Governmental and other authoritative entities of the (...) 31 countries were searched, and 1004 English-language documents containing ethical and/or methodological standards for clinical trials were identified. The authors extracted standards from 144 of those: 50 designated as ‘core’, 39 addressing trials of invasive procedures and a 5% sample of the remainder. As the integrating framework for the standards we developed a coherent taxonomy encompassing all elements of a trial's stages. Findings Review of the 144 documents yielded nearly 15 000 discrete standards. After duplicates were removed, 5903 substantive standards remained, distributed in the taxonomy as follows: initiation, 1401 standards, 8 divisions; design, 1869 standards, 16 divisions; conduct, 1473 standards, 8 divisions; analysing and reporting results, 997 standards, four divisions; and post-trial standards, 168 standards, 5 divisions. Conclusions The overwhelming number of source documents and standards uncovered in this study was not anticipated beforehand and confirms the extraordinary complexity of the clinical trials enterprise. This taxonomy of multinational ethical and methodological standards may help trialists and overseers improve the quality of clinical trials, particularly given the globalisation of clinical research. (shrink)

In this paper, we defend Socratic studies as a research programme against several recent attacks, including at least one recently published in Polis . Critics have argued that the study of Socrates, based upon evidence mostly or entirely derived from some set of Plato's dialogues, is founded upon faulty and indefensible historical or hermeneutical technique. We begin by identifying what we believe are the foundational principles of Socratic studies, as the field has been pursued in recent years, and we then (...) show how the research programme that derives from accepting these principles is not defeated by any of the most common recent criticisms of it. Specifically, we argue that challenges to sorting Plato's dialogues by date, more general challenges to historicist interpretations of Plato's dialogues, as well as recent literary criticisms of Socratic studies all fail to undermine the research programme. We conclude with some thoughts about how and why Socratic studies has proved itself a valuable and fruitful research programme. (shrink)

Objective: To examine the current ethical review process of ethics committees in a non-pharmacological trial from the perspective of a clinical investigator.Design: Prospective collection of data at the Study Centre of the German Surgical Society on the duration, costs and administrative effort of the ERP of a randomised controlled multicentre surgical INSECT Trial between November 2003 and May 2005.Setting: Germany.Participants: 18 ethics committees, including the ethics committee handling the primary approval, responsible overall for 32 clinical sites throughout Germany. 8 ethics (...) committees were located at university medical schools and 10 at medical chambers. Duration was measured as days between submission and receipt of final approval, costs in euros and administrative effort by calculation of the product of the total number of different types of documents and the mean number of copies required .Results: The duration of the ERP ranged from 1 to 176 days. The median duration was 26 days at MSUs compared with 34 days at medical chambers. The total cost was €2947. 1 of 8 ethics committees at universities and 8 of 10 at medical chambers charged a median fee of €162 . The administrative effort for primary approval was 30. Four ethics committees required a higher administrative effort for secondary approval .Conclusion: The ERP for non-pharmacological multicentre trials in Germany needs improvement. The administrative process has to be standardised: the application forms and the number and content of the documents required should be identical or at least similar. The fees charged vary considerably and are obviously too high for committees located at medical chambers. However, the duration of the ERP was, with some exceptions, excellent. A centralised ethics committee in Germany for multicentre trials such as the INSECT Trial can simplify the ERP for clinical investigators in and outside the country. (shrink)

In group discussions of any kind there tends to be an up and down in the level of deliberation. To capture this dynamic we coined the concept of Deliberative Transformative Moments (DTM). In deeply divided societies deliberation is particularly important in order to arrive at peace and stability, but deliberation is also very difficult to be attained. Therefore, we wanted to learn about the conditions that in group discussions across the deep divisions of such societies help deliberation. We organized such (...) group discussions between ex-guerrillas and ex-paramilitaries in Colombia, Serbs and Bosnjaks in Srebrenica, and poor residents and local police officers in the favelas (slums) of Brazil. We could identify factors that help to transform discussions from low to high deliberation and risk transformations in the opposite direction. We could also identify factors that help to keep a discussion at a high level of deliberation, and, in a next step, we could determine to what extent long sequences of deliberation had a positive impact on the outcomes of the discussions. Finally, we show how our research results can have a long term effect if it is used in schools of such deeply divided societies. (shrink)